Portal absorption of 14C after ingestion of spiked milk with 14C-phenanthrene, 14C-benzo[a]pyrene or 14C-TCDD in growing pigs

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Portal absorption of 14C after ingestion of spiked milk with 14C-phenanthrene, 14C-benzo[a]pyrene or 14C-TCDD in growing pigs.

Polycyclic aromatic hydrocarbons (PAHs) and dioxins are lipophilic organic pollutants occurring widely in the terrestrial environment. In order to study the PAHs and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) transfer in the food chain, pigs have been fed with milk mixed either with 14C-phenanthrene, with 14C-benzo[a]pyrene or with 14C-TCDD. The analysis of portal and arterial blood radioactivi...

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Metabolism of D-cephaloglycin-14C and L-cephaloglycin-14C in the rat.

The fate of the orally effective antibiotic D-cephaloglycin and its much less active L-enantiomer has been studied in the rat. D-Cephaloglycin-14C is metabolized by two pathways, (1) hydrolysis of the amide linkage to form D-2-phenylglycine-14C and (2) deacetylation to form deacetyl-D-cephaloglycinUC. D-Cephaloglycin is absorbed from the gastro-intestinal tract at least in part as the intact an...

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Chloroquine-resistant Plasmodium falciparum: difference in the handling of 14C-amodiaquin and 14C-chloroquine.

(14)C-amodiaquin and (14)C-chloroquine were used to study drug binding by preparations of owl monkey erythrocytes infected either with a chloroquine-susceptible (CS) or with a chloroquine-resistant (CR) strain of P. falciparum. Both of these drugs are derivatives of 4-aminoquinoline, but they differ in their side chains, and there are differences in the way they are handled by preparations of e...

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Incorporation of sodium acetate-1-14C into fatty acid-14C in the gingiva of scorbutic guinea pigs.

HoDGE[1] reported the determination of lipids in human gingiva. FISHER et al.[2] investigated into the cholesterol contents in bovine and human gingiva. STERN et al.[3] observed the incorporation of sodium acetate-1-14C into cholesterol, palmitic acid and oleic acid in human gingiva. OTAKE et al.[4] also reported the incorporationof sodium acetate-1-14C into the lipid fractions in guinea pig gi...

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Absorption, metabolism, and excretion of [14C]viramidine in humans.

Absorption, metabolism, and excretion of [14C]viramidine, a prodrug of ribavirin, were studied in humans following a single oral dose (600 mg). Viramidine was rapidly absorbed, with a time to maximum concentration of the drug in plasma of 1.5 h. Viramidine and ribavirin accounted for only 4.3% and 42% of plasma area under the concentration-time curve (AUC) for radioactivity, respectively, indic...

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ژورنال

عنوان ژورنال: Chemosphere

سال: 2002

ISSN: 0045-6535

DOI: 10.1016/s0045-6535(02)00145-5